Femara (letrozole) is a brand-name prescription drug used for certain types of breast cancer. Learn about side effects, off-label use for infertility, and more. “I’m on my third year of Femara and am tolerating it well. I categorize my side effects as ‘inconsistent and somewhat annoying.’ For example; I have sporadic instances of calf and arch cramps; intense sweating, joint pain and stiffness — but never all at once and not day after day. Find patient medical information for Letrozole (Femara) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Femara lowers estrogen levels and is used to treat breast cancer in postmenopausal women. Learn about side effects, interactions and indications. Femara is a treatment that may be used to reduce the risk of breast cancer recurrence in postmenopausal women and also to increase the chance of ovulation in women with polycystic ovary syndrome. Learn about side effects, cost, uses, and more of Femara (letrozole), which is a prescription drug that treats breast cancer in certain females. Drug Summary What Is Femara? Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women. Femara is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Femara is available in generic form. What Are Side Effects of Femara? Femara - Letrozole Tablets What is this medication? LETROZOLE (LET roe zole) treats some types of breast cancer. It works by decreasing the amount of estrogen hormone your body makes, which slows or stops breast cancer cells from spreading or growing. Femara 2.5mg Tablet is used in the treatment of hormone-sensitive breast cancer, especially in postmenopausal women. It helps lower the risk of cancer returning and supports long-term recovery after initial treatment. Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women.